Auditory nerve responses to combined optogenetic and electrical stimulation in chronically deaf mice

EA Ajay; EP Trang; AC Thompson; AK Wise; DB Grayden; JB Fallon; RT Richardson

Journal article

Auditory nerve responses to combined optogenetic and electrical stimulation in chronically deaf mice

EA Ajay, EP Trang, AC Thompson, AK Wise, DB Grayden, JB Fallon, RT Richardson

Journal of Neural Engineering | Published : 2023

DOI: 10.1088/1741-2552/acc75f

Abstract

Objective. Optogenetic stimulation of the auditory nerve offers the ability to overcome the limitations of cochlear implants through spatially precise stimulation, but cannot achieve the temporal precision nor temporal fidelity required for good hearing outcomes. Auditory midbrain recordings have indicated a combined (hybrid) stimulation approach may permit improvements in the temporal precision without sacrificing spatial precision by facilitating electrical activation thresholds. However, previous research has been conducted in undeafened or acutely deafened animal models, and the impact of chronic deafness remains unclear. Our study aims to compare the temporal precision of auditory nerve..

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University of Melbourne Researchers

Alexander Thompson Author

Andrew Wise Author

David Grayden Author

James Fallon Author

Related Projects (1)

Hybrid optical-electrical stimulation for precise neural stimulation

In world-first research, we have evidence that combining electrical stimulation with optical stimulation significantly and safely improves p..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

<STRONG> </STRONG>The research in this publication was supported with funding from the National Health and Medical Research Council (NHMRC) GNT#2002523 and by an Australian Government Research Training Program (RTP) Scholarship. The Bionics Institute acknowledges the support they receive from the Victorian Government through its Operational Infrastructural Support Program.